Sphingolipids and their metabolism in physiology and disease
Sphingolipids and their metabolism in physiology and disease
Sphingolipids and their metabolism in physiology and disease, Published online: 22 November 2017; doi:10.1038/nrm.2017.107
Sphingolipids are a major class of lipids, comprising various species with diverse functions. In addition to being structural elements of membranes, many sphingolipids are bioactive and regulate a myriad of cellular processes. Recent advances have shed new light on the complexity of sphingolipid metabolism and their various roles in physiology and disease.